D/D of Iris Nodules –

1. Tumors

• Benign:
  • Iris nevus
  • Iridocorneal endothelial syndrome (ICE)
  • Oculodermal melanosis (nevus of Ota)
• Malignant:
  • Primary:
    • Malignant melanoma
    • Leiomyoma
    • Leukemia
  • Secondary

2. Non tumours conditions

• Infection/inflammation:
  • Granulomatous uveitis (Koeppe and Busacca nodules)
  • Fungal endophthalmitis
• Trauma:
  • Inclusion cyst
  • Retained IOFB
• Developmental:
  • Neurofibromatosis (Lisch’s nodule)
  • Down’s syndrome (Brushfield spots)
  • Juvenile xanthogranuloma